Lrp4^tm1.1Mkne
Targeted Allele Detail

Summary

• Symbol: Lrp4^tm1.1Mkne
• Name: low density lipoprotein receptor-related protein 4; targeted mutation 1.1, Michaela Kneissel
• MGI ID: MGI:5660882
• Synonyms: Lrp4^flox
• Gene: Lrp4 Location: Chr2:91287856-91344124 bp, + strand Genetic Position: Chr2, 50.63 cM
• Alliance: Lrp4^tm1.1Mkne page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:216649
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6

Mutation description

• Allele Type: Targeted (Conditional ready)
• Mutation: Insertion
• Mutation details: Exon 1 was floxed and an FRT flanked neo cassette was inserted via homologous recombination. Flp mediated recombination removed the neo cassette. (J:216649)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Lrp4 Mutation: 96 strains or lines available

References

• Original: J:216649 Chang MK, et al., Disruption of Lrp4 function by genetic deletion or pharmacological blockade increases bone mass and serum sclerostin levels. Proc Natl Acad Sci U S A. 2014 Dec 2;111(48):E5187-95
• All: 1 reference(s)