Mastl^tm1.1Kald
Targeted Allele Detail

Summary

• Symbol: Mastl^tm1.1Kald
• Name: microtubule associated serine/threonine kinase-like; targeted mutation 1.1, Philipp Kaldis
• MGI ID: MGI:5660412
• Synonyms: Mastl^FLOX
• Gene: Mastl Location: Chr2:23006549-23046036 bp, - strand Genetic Position: Chr2, 15.23 cM
• Alliance: Mastl^tm1.1Kald page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:215974
• Parent Cell Line: S1B6 (ES Cell)
• Strain of Origin: 129S1/SvImJ or C57BL/6J

Mutation description

• Allele Type: Targeted (Conditional ready)
• Mutation: Insertion
• Mutation details: A loxP site was inserted upstream of exon 4 and an FRT flanked neo cassette and loxP site were inserted downstream of exon 4 via homologous recombination. Flp mediated recombination removed the neo cassette. (J:215974)

Expression

In Mice Carrying this Mutation:

12 assay results

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Mastl Mutation: 36 strains or lines available

References

• Original: J:215974 Adhikari D, et al., Mastl is required for timely activation of APC/C in meiosis I and Cdk1 reactivation in meiosis II. J Cell Biol. 2014 Sep 29;206(7):843-53
• All: 3 reference(s)