Dcn^tm1.2Geno
Targeted Allele Detail

Summary

• Symbol: Dcn^tm1.2Geno
• Name: decorin; targeted mutation 1.2, Genoway
• MGI ID: MGI:5660397
• Gene: Dcn Location: Chr10:97315471-97354005 bp, + strand Genetic Position: Chr10, 50.27 cM
• Alliance: Dcn^tm1.2Geno page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:223791
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129S2/SvPas

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The targeting vector is designed to insert a loxP site upstream of exon 8, and a FRT-flanked neomycin resistance cassette followed by a second loxP site downstream of exon 8. Exon 8 also contains a 952delT mutation that corresponds to the 967delT human mutation associated with autosomal dominant congenital stromal corneal dystrophy (CSCD). Flp-mediated recombination removed the FRT-flanked neo cassette and cre-mediated recombination removed exon 8. (J:223791)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Dcn Mutation: 27 strains or lines available

References

• Original: J:223791 Mellgren AE, et al., Development of congenital stromal corneal dystrophy is dependent on export and extracellular deposition of truncated decorin. Invest Ophthalmol Vis Sci. 2015 May;56(5):2909-15
• All: 2 reference(s)