Cdh5^tm1.1Ics
Targeted Allele Detail

Summary

• Symbol: Cdh5^tm1.1Ics
• Name: cadherin 5; targeted mutation 1.1, Mouse Clinical Institute
• MGI ID: MGI:5647997
• Synonyms: VE-Y685F
• Gene: Cdh5 Location: Chr8:104828257-104871143 bp, + strand Genetic Position: Chr8, 53.04 cM
• Alliance: Cdh5^tm1.1Ics page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:214298
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129

Mutation description

• Allele Type: Targeted (Not Specified)
• Mutations: Insertion, Single point mutation
• Mutation details: A T-to-C mutation at codon 685 (creating a p.Tyr685Phe amino-acid change) was introduced into exon 12 and a floxed neomycin resistance gene cassette was inserted into intron 12. Cre-mediated recombination removed the neo cassette. (J:214298)

Expression

In Structures Affected by this Mutation:

7 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Cdh5 Mutation: 53 strains or lines available

References

• Original: J:214298 Sidibe A, et al., VE-cadherin Y685F knock-in mouse is sensitive to vascular permeability in recurrent angiogenic organs. Am J Physiol Heart Circ Physiol. 2014 Aug 1;307(3):H455-63
• All: 1 reference(s)