Tg(Vav1-EIF2AK2*K296R)1Wsmay
Transgene Detail

Summary

• Symbol: Tg(Vav1-EIF2AK2*K296R)1Wsmay
• Name: transgene insertion 1, W May
• MGI ID: MGI:5646211
• Synonyms: TgDNPKR
• Transgene: Tg(Vav1-EIF2AK2*K296R)1Wsmay Location: unknown
• Alliance: Tg(Vav1-EIF2AK2*K296R)1Wsmay page

Transgene origin

• Strain of Origin: C57BL/6

Transgene description

• Transgene Type: Transgenic (Humanized sequence, Inserted expressed sequence)
• Mutation: Insertion
• Tg(Vav1-EIF2AK2*K296R)1Wsmay expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  EIF2AK2 (5610)

  Eif2ak2

  (MGI:1353449)

  The cDNA carries the K296R mutation.

• Mutation details: The transgene consists of mouse vav 1 oncogene promoter/control regions directing expression of a catalytically-null/dominant-negative (K296R) mutant variant of human eukaryotic translation initiation factor 2-alpha kinase 2 cDNA sequence. (J:196300)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available

References

• Original: J:196300 Liu X, et al., PKR regulates proliferation, differentiation, and survival of murine hematopoietic stem/progenitor cells. Blood. 2013 Apr 25;121(17):3364-74
• All: 1 reference(s)