Tg(Nos2-tdTomato,-cre)1Albe
Transgene Detail

Summary

• Symbol: Tg(Nos2-tdTomato,-cre)1Albe
• Name: transgene insertion 1, Alain Bessis
• MGI ID: MGI:5645754
• Synonyms: NOS2-Tomato-Cre
• Transgene: Tg(Nos2-tdTomato,-cre)1Albe Location: unknown
• Alliance: Tg(Nos2-tdTomato,-cre)1Albe page

Transgene origin

• Strain of Origin: C57BL/6J

Transgene description

• Transgene Type: Transgenic (Recombinase, Reporter)
• Mutation: Insertion
• Tg(Nos2-tdTomato,-cre)1Albe expression driven by 1 gene
  Transgene expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Nos2 (MGI:97361)

• Mutation details: A tdTomato-IRESs-Cre cassette was inserted by homologous recombination into the RP23-341J22 bacterial artificial chromosome (BAC) that contains 146 kb upstream and 73 kb downstream of the 39kb Nos2 gene. The cassette was inserted into exon 2 with the ATG of the tdTomato replacing the endogenous ATG. The recombined BAC was then used to generate the transgenic mouse. The expression of tdTomato and CRE recombinase faithfully recapitulates the endogenous expression of NOS2. (J:209609)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Nos2 (mouse) Summary of all recombinase alleles driven by Nos2. Alliance mouse Nos2 gene page

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available

References

• Original: J:209609 Bechade C, et al., NOS2 expression is restricted to neurons in the healthy brain but is triggered in microglia upon inflammation. Glia. 2014 Jun;62(6):956-63
• All: 4 reference(s)