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Transgene Detail
Symbol: Tg(Nos2-tdTomato,-cre)1Albe
Name: transgene insertion 1, Alain Bessis
MGI ID: MGI:5645754
Synonyms: NOS2-Tomato-Cre
Transgene: Tg(Nos2-tdTomato,-cre)1Albe  Location: unknown  
Alliance: Tg(Nos2-tdTomato,-cre)1Albe page
Strain of Origin:  C57BL/6J
Transgene Type:    Transgenic (Recombinase, Reporter)
Mutation:    Insertion
Tg(Nos2-tdTomato,-cre)1Albe expression driven by 1 gene
Mutation detailsA tdTomato-IRESs-Cre cassette was inserted by homologous recombination into the RP23-341J22 bacterial artificial chromosome (BAC) that contains 146 kb upstream and 73 kb downstream of the 39kb Nos2 gene. The cassette was inserted into exon 2 with the ATG of the tdTomato replacing the endogenous ATG. The recombined BAC was then used to generate the transgenic mouse. The expression of tdTomato and CRE recombinase faithfully recapitulates the endogenous expression of NOS2. (J:209609)
 Tissue activity of this recombinase allele
Driver: Nos2 (mouse)
Summary of all recombinase alleles driven by Nos2.

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Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Original:  J:209609 Bechade C, et al., NOS2 expression is restricted to neurons in the healthy brain but is triggered in microglia upon inflammation. Glia. 2014 Jun;62(6):956-63
All:  4 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
MGI 6.24
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