Usp28^tm1.1Axbe
Targeted Allele Detail

Summary

• Symbol: Usp28^tm1.1Axbe
• Name: ubiquitin specific peptidase 28; targeted mutation 1, Axel Behrens
• MGI ID: MGI:5645115
• Synonyms: Usp28^fl
• Gene: Usp28 Location: Chr9:48896675-48953817 bp, + strand Genetic Position: Chr9, 26.56 cM
• Alliance: Usp28^tm1.1Axbe page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:213781
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Conditional ready)
• Mutation: Insertion
• Mutation details: Exons 4 and 5 were floxed and an Frt flanked neo cassette was inserted in intron 3 via homologous recombination. Flp mediated recombination removed the neo cassette. (J:213781)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Usp28 Mutation: 81 strains or lines available

References

• Original: J:213781 Diefenbacher ME, et al., The deubiquitinase USP28 controls intestinal homeostasis and promotes colorectal cancer. J Clin Invest. 2014 Aug 1;124(8):3407-18
• All: 7 reference(s)