El7^EL
QTL Variant Detail

Summary

• QTL variant: El7^EL
• Name: epilepsy 7; EL
• MGI ID: MGI:5644570
• QTL: El7 Location: Chr9:75682646-114303447 bp Genetic Position: Chr9, Syntenic

Variant origin

• Strain of Specimen: EL

Variant description

• Allele Type: QTL

Notes

Mapping and Phenotype information for this QTL, its variants and associated markers

J:11381

(DBA/2J x EL)F1 x DBA/2J and (ABP/LeJ x EL)F1 x ABP/LeJ backcross populations were used to map QTLs associated with susceptibility to epileptic seizures. Parental strain EL is highly susceptible to epileptic seizures whereas parental strains DBA/2J and ABP/LeJ are resistant. F1 hybrid animals exhibit seizure susceptibility to a lesser degree than parental strain EL.

A locus with significant association to epileptic seizures, El1, was detected on mouse Chromosome 9 (P<0.001) in both backcross populations. El1 maps near Mpmv27, Myo5a, Bmp5, and Glb1 and gives a peak LOD score of 5.88 between Glb1 and Bmp5.

7.13.2015 Curator Note: Because two different crosses were used in this study we consider each QTL to be unique. We have left the QTL identified here, using the (DBA/2J x EL)F1 x DBA/2J backcross, with the original El1 nomenclature. We have named the QTL identified using the (ABP/LeJ x EL)F1 x ABP/LeJ backcross as El7.

A locus significantly linked to seizures, El2, was detected on mouse Chromosome 2(P<0.001) in the (ABP/LeJ x EL)F1 x ABP/LeJ backcross population. El2 is linked to Mpmv28 with a peak LOD score of 5.2.

References

• Original: J:11381 Rise ML, et al., Genes for epilepsy mapped in the mouse. Science. 1991 Aug 9;253(5020):669-73
• All: 1 reference(s)