Nfkb1^tm1.1Dkam
Targeted Allele Detail

Summary

• Symbol: Nfkb1^tm1.1Dkam
• Name: nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105; targeted mutation 1.1, Derek A Mann
• MGI ID: MGI:5643936
• Synonyms: Nfkb1^S340A
• Gene: Nfkb1 Location: Chr3:135290416-135397308 bp, - strand Genetic Position: Chr3, 62.82 cM
• Alliance: Nfkb1^tm1.1Dkam page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:222083
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Not Applicable)
• Mutations: Insertion, Nucleotide substitutions
• Mutation details: Exon 12 was replaced with a modified exon containing nucleotide substitutions that resulted in the amino acid substitution of alanine for serine at position 340 (S340A). Cre-mediated recombination removed the floxed neomycin resistance inserted downstream of the modified exon. (J:222083)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Nfkb1 Mutation: 104 strains or lines available

References

• Original: J:222083 Wilson CL, et al., NFkappaB1 is a suppressor of neutrophil-driven hepatocellular carcinoma. Nat Commun. 2015;6:6818
• All: 1 reference(s)