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QTL Variant Detail
QTL variant: Albq14CBA/J
Name: albuminuria QTL 14; CBA/J
MGI ID: MGI:5642001
QTL: Albq14  Location: unknown  Genetic Position: Chr7, Syntenic
Strain of Specimen:  CBA/J
Allele Type:    QTL
Inheritance:    Not Specified

Mapping and Phenotype information for this QTL, its variants and associated markers


QTL Reference Notes

The Collaborative Cross (CC) is a large (~1,000 line) panel of recombinant inbred (RI) mouse strains being developed through a community effort (Churchill et al. 2004). The CC combines the genomes of eight genetically diverse founder strains - A/J, C57BL/6J, 129S1/SvImJ, NOD/ShiLtJ, NZO/HlLtJ, CAST/EiJ, PWK/PhJ, and WSB/EiJ - to capture nearly 90% of the known variation present in laboratory mice. CC strains are derived using a unique funnel breeding scheme. Once inbred, the RI CC lines can be used to generate thousands of potential 'outbred' but completely reproducible genomes through the generation of recombinant inbred crosses (RIX). The designation 'PreCC' is used to describe a mapping population of CC mice that is still at insipient stages of inbreeding. CTC (2004), Churchill, G. A., et al.. The Collaborative Cross, a community resource for the genetic analysis of complex traits. Nat Genet. 36, 1133-7.

Linkage analysis was performed on 324 (PL/J x CBA/J)F2 intercross mice using 90 markers to identify QTL associated with albuminuria. Parental strain PL/J exhibits higher incidence of albuminuria when compared to CBA/J.

QTL Albq14 maps to 70.0 - 138.7 Mb on Chromosome 7 with a peak LOD score of 3.32 at 64.4 cM in linkage with albuminuria. PL/J alleles confer increased susceptibility to albuminuria.

Original:  J:188618 Thaisz J, et al., Genetic analysis of albuminuria in collaborative cross and multiple mouse intercross populations. Am J Physiol Renal Physiol. 2012 Oct;303(7):F972-81
All:  1 reference(s)

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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