Tg(ACTA1-DMD*)326Dua
Transgene Detail

Summary

• Symbol: Tg(ACTA1-DMD*)326Dua
• Name: transgene insertion 326, Dongsheng Duan
• MGI ID: MGI:5641706
• Synonyms: deltaR4-23/deltaC
• Transgene: Tg(ACTA1-DMD*)326Dua Location: unknown
• Alliance: Tg(ACTA1-DMD*)326Dua page

Transgene origin

• Strain of Origin: FVB/N

Transgene description

• Transgene Type: Transgenic (Humanized sequence, Inserted expressed sequence)
• Mutation: Insertion
• Tg(ACTA1-DMD*)326Dua expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  DMD (1756)

  Dmd	(MGI:94909)

  Full length human dystrophin cDNA is modified by the deletion of repeat 4 to 23 and the C-terminus.

• Mutation details: The transgenic construct contains a full length human dystrophin gene modified by the deletion of repeat 4 through repeat 23 and the C-terminus to generate a micro-dystrophin cDNA (deltaR4-23/deltaC) under the control of the human skeletal alpha 1 actin (ACTA1) promoter. (J:167308)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available

References

• Original: J:167308 Li D, et al., Nitrosative stress elicited by nNOSmicro delocalization inhibits muscle force in dystrophin-null mice. J Pathol. 2011 Jan;223(1):88-98
• All: 4 reference(s)