Casz1^{tm2(cre/ERT2)Flc}
Targeted Allele Detail

Summary

• Symbol: Casz1^{tm2(cre/ERT2)Flc}
• Name: castor zinc finger 1; targeted mutation 2, Frank Conlon
• MGI ID: MGI:5638932
• Synonyms: Casz1^CreERT2
• Gene: Casz1 Location: Chr4:148888886-149039346 bp, + strand Genetic Position: Chr4, 78.87 cM
• Alliance: Casz1^{tm2(cre/ERT2)Flc} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:221324
• Parent Cell Line: E14 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Conditional ready, Inducible, Recombinase)
• Inducer: tamoxifen
• Mutation: Insertion
• Casz1^{tm2(cre/ERT2)Flc} expression driven by 1 gene
  Knock-in expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Casz1 (MGI:1196251)

• Mutation details: An FRT-flanked inducible cre recombinase fusion gene (cre/ERT2) and neomycin resistance cassette with a 3' loxP site was inserted upstream of exon 6. An additional loxP site was inserted downstream of exon 6. (J:221324)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Casz1 (mouse) Summary of all recombinase alleles driven by Casz1. Alliance mouse Casz1 gene page

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Casz1 Mutation: 344 strains or lines available

References

• Original: J:221324 Dorr KM, et al., Casz1 is required for cardiomyocyte G1-to-S phase progression during mammalian cardiac development. Development. 2015 Jun 1;142(11):2037-47
• All: 1 reference(s)