Gpat3^tm1Reg
Targeted Allele Detail

Summary

• Symbol: Gpat3^tm1Reg
• Name: glycerol-3-phosphate acyltransferase 3; targeted mutation 1, Ruth E Gimeno
• MGI ID: MGI:5638667
• Synonyms: Gpat3^-
• Gene: Gpat3 Location: Chr5:100994095-101046968 bp, + strand Genetic Position: Chr5, 48.52 cM
• Alliance: Gpat3^tm1Reg page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:213618
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: A genomic region including exons 4 - 7 was replaced with a neo cassette via homologous recombination. qPCR analysis confirmed the absence of intact mRNA transcripts in total RNA samples isolated from liver and white adipose tissue (WAT) of homozygous mutant mice. (J:213618)

Expression

In Structures Affected by this Mutation:

5 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Gpat3 Mutation: 20 strains or lines available

References

• Original: J:213618 Cao J, et al., Mice deleted for GPAT3 have reduced GPAT activity in white adipose tissue and altered energy and cholesterol homeostasis in diet-induced obesity. Am J Physiol Endocrinol Metab. 2014 May 15;306(10):E1176-87
• All: 4 reference(s)