Glp1r^tm1Ssis
Targeted Allele Detail

Summary

• Symbol: Glp1r^tm1Ssis
• Name: glucagon-like peptide 1 receptor; targeted mutation 1, Stephanie Sisley
• MGI ID: MGI:5637837
• Synonyms: Glp1r^flox
• Gene: Glp1r Location: Chr17:31120841-31155484 bp, + strand Genetic Position: Chr17, 15.8 cM
• Alliance: Glp1r^tm1Ssis page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:212938
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129

Mutation description

• Allele Type: Targeted (Conditional ready)
• Mutation: Insertion
• Mutation details: A loxP site and FRT flanked neo cassette were inserted upstream of exon 6 and a loxP site was inserted downstream of exon 7 via homologous recombination. (J:212938)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Glp1r Mutation: 54 strains or lines available

References

• Original: J:212938 Sisley S, et al., Neuronal GLP1R mediates liraglutide's anorectic but not glucose-lowering effect. J Clin Invest. 2014 Jun 2;124(6):2456-63
• All: 14 reference(s)