Celsr2^tm1.2Agof
Targeted Allele Detail

Summary

• Symbol: Celsr2^tm1.2Agof
• Name: cadherin, EGF LAG seven-pass G-type receptor 2; targeted mutation 1.2, Andre M Goffinet
• MGI ID: MGI:5637346
• Synonyms: Celsr2^-
• Gene: Celsr2 Location: Chr3:108298167-108323383 bp, - strand Genetic Position: Chr3, 47.02 cM
• Alliance: Celsr2^tm1.2Agof page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:212261
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A loxP and FRT flanked neo cassette were inserted into intron 15 and a loxP site was inserted into intron 28 via homologous recombination. Flp mediated recombination removed the neo cassette. Cre mediated recombination removed exons 16-28. No protein expression was detected in homozygous mice using a C-terminal antibody. (J:212261)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Celsr2 Mutation: 112 strains or lines available

References

• Original: J:212261 Qu Y, et al., Genetic evidence that Celsr3 and Celsr2, together with Fzd3, regulate forebrain wiring in a Vangl-independent manner. Proc Natl Acad Sci U S A. 2014 Jul 22;111(29):E2996-3004
• All: 2 reference(s)