Myc^tm5.1Fwa
Targeted Allele Detail

Summary

• Symbol: Myc^tm5.1Fwa
• Name: Myc proto-oncogene, bHLH transcription factor; targeted mutation 5.1, Frederick W Alt
• MGI ID: MGI:5636851
• Synonyms: c-myc^1xI-SceI
• Gene: Myc Location: Chr15:61857240-61862223 bp, + strand Genetic Position: Chr15, 26.19 cM, cytoband D2-D3
• Alliance: Myc^tm5.1Fwa page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:220884
• Parent Cell Line: TC1/TC-1 (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted (Not Applicable)
• Mutation: Insertion
• Mutation details: A floxed selection cassette and a single I-SceI site were inserted into intron 1 via homologous recombination. Cre mediated recombination removed the neo cassette. (J:220884)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Myc Mutation: 42 strains or lines available

References

• Original: J:220884 Chiarle R, et al., Genome-wide translocation sequencing reveals mechanisms of chromosome breaks and rearrangements in B cells. Cell. 2011 Sep 30;147(1):107-19
• All: 2 reference(s)