Glp1r^{tm1.1(GLP1R)Arte}
Targeted Allele Detail

Summary

• Symbol: Glp1r^{tm1.1(GLP1R)Arte}
• Name: glucagon-like peptide 1 receptor; targeted mutation 1.1, TaconicArtemis
• MGI ID: MGI:5636654
• Gene: Glp1r Location: Chr17:31120841-31155484 bp, + strand Genetic Position: Chr17, 15.8 cM
• Alliance: Glp1r^{tm1.1(GLP1R)Arte} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:219255
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6NTac

Mutation description

• Allele Type: Targeted (Humanized sequence, Inserted expressed sequence)
• Mutations: Insertion, Intragenic deletion
• Glp1r^{tm1.1(GLP1R)Arte} expresses 1 gene
  Knock-in expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  GLP1R (2740)

  Glp1r

  (MGI:99571)

  FLAG-tagged

• Mutation details: The targeted construct replaced the coding sequence of exon 1 with the coding sequence from human exon 1, a loxP site, an FRT-flanked neomycin resistance cassette, the human sequence for exon 3 through 13, a FLAG-tag, the mouse 3' untranslated region, an F3-flanked puromycin resistance cassette, a loxP site and polyadenylation sequence. Flp-mediated recombination removed both selection cassette. (J:219255)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Glp1r Mutation: 52 strains or lines available

References

• Original: J:219255 Jun LS, et al., A novel humanized GLP-1 receptor model enables both affinity purification and Cre-LoxP deletion of the receptor. PLoS One. 2014;9(4):e93746
• All: 6 reference(s)