Gt(ROSA)26Sor^{tm10(Nfatc1)Arte}
Targeted Allele Detail

Summary

• Symbol: Gt(ROSA)26Sor^{tm10(Nfatc1)Arte}
• Name: gene trap ROSA 26, Philippe Soriano; targeted mutation 10, TaconicArtemis
• MGI ID: MGI:5636612
• Synonyms: c.n.Nfatc1, Gt(ROSA)26Sor^{tm1(Nfatc1)Arte}
• Gene: Gt(ROSA)26Sor Location: Chr6:113044389-113054205 bp, - strand Genetic Position: Chr6, 52.73 cM
• Alliance: Gt(ROSA)26Sor^{tm10(Nfatc1)Arte} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:213422
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Conditional ready, Constitutively active, Inserted expressed sequence)
• Mutation: Insertion
• Gt(ROSA)26Sor^{tm10(Nfatc1)Arte} expresses 1 gene
  Knock-in expresses:
  

  Organism	Expressed Gene	Note
  mouse	Nfatc1 (MGI:102469)	Constitutively active

• Mutation details: The targeting vector introduced into the locus a floxed splice acceptor and neomycin resistance cassette and an N-terminally HA-tagged constitutively active sequence with serine to alanine substitutions in the conserved serine-rich domain and all three serine-proline repeats. (J:213422)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Gt(ROSA)26Sor Mutation: 1205 strains or lines available

References

• Original: J:213422 Baumgart S, et al., Inflammation-induced NFATc1-STAT3 transcription complex promotes pancreatic cancer initiation by KrasG12D. Cancer Discov. 2014 Jun;4(6):688-701
• All: 6 reference(s)