Mzb1^tm1.2Rug
Targeted Allele Detail

Summary

• Symbol: Mzb1^tm1.2Rug
• Name: marginal zone B and B1 cell-specific protein 1; targeted mutation 1.2, Rudolf Grosschedl
• MGI ID: MGI:5636602
• Synonyms: Mzb1^-
• Gene: Mzb1 Location: Chr18:35780320-35782420 bp, - strand Genetic Position: Chr18, 19.19 cM
• Alliance: Mzb1^tm1.2Rug page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:211639
• Parent Cell Line: D3 (ES Cell)
• Strain of Origin: 129S2/SvPas

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A loxP site was inserted into intron 1 and an FRT site flanked neomycin resistance gene cassette, loxP site, and splice acceptor and EGFP cassette were inserted into intron 4 via homologous recombination. Subsequent flp-mediated recombination removed the neo cassette and cre-mediated recombination deleted exons 2-4. (J:211639)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Mzb1 Mutation: 10 strains or lines available

References

• Original: J:211639 Rosenbaum M, et al., MZB1 is a GRP94 cochaperone that enables proper immunoglobulin heavy chain biosynthesis upon ER stress. Genes Dev. 2014 Jun 1;28(11):1165-78
• All: 3 reference(s)