Sh2d1b1^tm4.1Vei
Targeted Allele Detail

Summary

• Symbol: Sh2d1b1^tm4.1Vei
• Name: SH2 domain containing 1B1; targeted mutation 4.1, Andre Veillette
• MGI ID: MGI:5636596
• Synonyms: EAT-2^KI, Sh2d1b1^Y120,127F
• Gene: Sh2d1b1 Location: Chr1:170104889-170114338 bp, + strand Genetic Position: Chr1, 76.84 cM, cytoband H2
• Alliance: Sh2d1b1^tm4.1Vei page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:212410
• Parent Cell Line: Bruce 4 (ES Cell)
• Strain of Origin: B6.Cg-Thy1^a

Mutation description

• Allele Type: Targeted (Not Applicable)
• Mutations: Insertion, Nucleotide substitutions
• Mutation details: Exons 3 and 4 were replaced with modified exons in which nucleotide substitution result in the amino acid substitutions of phenylalanine for tyrosine at positions 120 and 127 (Y120F, Y127F). Flp-mediated recombination removed the FRT-flanked neomycin resistance cassette with a 5' loxP site inserted between the modified exons. An additional loxP site is located downstream of exon 4. (J:212410)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Sh2d1b1 Mutation: 10 strains or lines available

References

• Original: J:212410 Perez-Quintero LA, et al., EAT-2, a SAP-like adaptor, controls NK cell activation through phospholipase Cgamma, Ca++, and Erk, leading to granule polarization. J Exp Med. 2014 Apr 7;211(4):727-42
• All: 1 reference(s)