Ephx2^tm2.1Arte
Targeted Allele Detail

Summary

• Symbol: Ephx2^tm2.1Arte
• Name: epoxide hydrolase 2, cytoplasmic; targeted mutation 2.1, TaconicArtemis
• MGI ID: MGI:5636595
• Synonyms: Cys521Ser
• Gene: Ephx2 Location: Chr14:66321823-66361949 bp, - strand Genetic Position: Chr14, 34.36 cM, cytoband D
• Alliance: Ephx2^tm2.1Arte page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:211353
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6N

Mutation description

• Allele Type: Targeted (Not Specified)
• Mutation: Nucleotide substitutions
• Mutation details: A Cys521Ser substitution was introduced into exon 18 by changing a TGT codon to a TCC codon and an F3 flanked puro selection cassette was introduced into intron 16 via homologous recombination. Flp mediated recombination removed the selection cassette. This mutation prevents hydrolysis of the enzyme's epoxyeicosatrienoic acid (EET) substrates. (J:211353)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ephx2 Mutation: 39 strains or lines available

References

• Original: J:211353 Charles RL, et al., Protection from hypertension in mice by the Mediterranean diet is mediated by nitro fatty acid inhibition of soluble epoxide hydrolase. Proc Natl Acad Sci U S A. 2014 Jun 3;111(22):8167-72
• All: 2 reference(s)