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Grxcr2tm1.1Dck
Targeted Allele Detail
Summary
Symbol: Grxcr2tm1.1Dck
Name: glutaredoxin, cysteine rich 2; targeted mutation 1.1, David Kohrman
MGI ID: MGI:5636505
Synonyms: Grxcr2delta
Gene: Grxcr2  Location: Chr18:42118388-42132114 bp, - strand  Genetic Position: Chr18, 22.14 cM
Alliance: Grxcr2tm1.1Dck page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:265041
Parent Cell Line:  Bruce 4 (ES Cell)
Strain of Origin:  B6.Cg-Thy1a
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA loxP site was inserted upstream of exon 1. An FRT-flanked neomycin resistance cassette with a 5' loxP site was inserted downstream of exon 1. Cre-mediated recombination removed exon 1. Immunoreactivity confirmed the absence of protein expression in cochlear stereocilia bundles. (J:265041)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 1 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Grxcr2 Mutation:  13 strains or lines available
References
Original:  J:265041 Avenarius MR, et al., Grxcr2 is required for stereocilia morphogenesis in the cochlea. PLoS One. 2018;13(8):e0201713
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
07/02/2024
MGI 6.13
The Jackson Laboratory