Zbtb46tm1.1Kmm
Targeted Allele Detail
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Symbol: |
Zbtb46tm1.1Kmm |
Name: |
zinc finger and BTB domain containing 46; targeted mutation 1.1, Kenneth Murphy |
MGI ID: |
MGI:5636376 |
Synonyms: |
Zbtb46GFP |
Gene: |
Zbtb46 Location: Chr2:181029555-181101219 bp, - strand Genetic Position: Chr2, 103.63 cM, cytoband H4
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Alliance: |
Zbtb46tm1.1Kmm page
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Germline Transmission: |
Earliest citation of germline transmission:
J:184205
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Parent Cell Line: |
EDJ22 (ES Cell)
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Strain of Origin: |
129S6/SvEvTac
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Allele Type: |
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Targeted (Null/knockout, Reporter) |
Mutations: |
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Insertion, Intragenic deletion
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Mutation details: A targeting vector was designed to replace exon 2, which encodes the start codon and the BTB domain of the zinc finger and BTB domain, with an enhanced green fluorescent protein followed by a polyadenylation signal and a floxed neo cassette. Microarray analysis confirmed the absence of transcript expression in dendritic cells. Cre-mediated recombination removed the floxed neo cassette.
(J:184205)
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Original: |
J:184205 Satpathy AT, et al., Zbtb46 expression distinguishes classical dendritic cells and their committed progenitors from other immune lineages. J Exp Med. 2012 Jun 4;209(6):1135-52 |
All: |
38 reference(s) |
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