Crp^tm1.1Mpe
Targeted Allele Detail

Summary

• Symbol: Crp^tm1.1Mpe
• Name: C-reactive protein, pentraxin-related; targeted mutation 1.1, Mark B Pepys
• MGI ID: MGI:5635804
• Gene: Crp Location: Chr1:172525623-172527533 bp, + strand Genetic Position: Chr1, 80.13 cM
• Alliance: Crp^tm1.1Mpe page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:212127
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: An FRT-flanked neomycin resistance cassette replaced the coding sequence. Flp-mediated recombination removed the selection cassette. (J:212127)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Crp Mutation: 20 strains or lines available

References

• Original: J:212127 Simons JP, et al., C-reactive protein is essential for innate resistance to pneumococcal infection. Immunology. 2014 Jul;142(3):414-20
• All: 1 reference(s)