Uchl1^tm1Crjk
Targeted Allele Detail

Summary

• Symbol: Uchl1^tm1Crjk
• Name: ubiquitin carboxy-terminal hydrolase L1; targeted mutation 1, Chris Kennedy
• MGI ID: MGI:5635500
• Gene: Uchl1 Location: Chr5:66833464-66844577 bp, + strand Genetic Position: Chr5, 35.95 cM
• Alliance: Uchl1^tm1Crjk page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:212476
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• A pgk-neomycin resistance cassette replaced a genomic region spanning exon 4. (J:212476, J:288955)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Uchl1 Mutation: 33 strains or lines available

References

• Original: J:212476 Read NC, et al., Ubiquitin C-terminal hydrolase L1 deletion ameliorates glomerular injury in mice with ACTN4-associated focal segmental glomerulosclerosis. Biochim Biophys Acta. 2014 Jul;1842(7):1028-40
• All: 3 reference(s)