Tg(Lck-Ppp3ca*)28Naka
Transgene Detail

Summary

• Symbol: Tg(Lck-Ppp3ca*)28Naka
• Name: transgene insertion 28, Toshinori Nakayama
• MGI ID: MGI:5635497
• Synonyms: dnCN Tg
• Transgene: Tg(Lck-Ppp3ca*)28Naka Location: unknown
• Alliance: Tg(Lck-Ppp3ca*)28Naka page

Transgene origin

• Strain of Origin: C57BL/6

Transgene description

• Transgene Type: Transgenic (Dominant negative, Inserted expressed sequence)
• Mutation: Insertion
• Tg(Lck-Ppp3ca*)28Naka expresses 1 gene
  Transgene expresses:
  

  Organism	Expressed Gene	Note
  mouse	Ppp3ca (MGI:107164)	Modified to delete sequence encoding five amino acid residues in the phosphatase active site.

• Mutation details: This transgene expresses a dominant negative mutated form of Ppp3ca under the control of the Lck proximal promoter. Sequence encoding five amino acid residues in the phosphatase active site (148-52) was deleted. Three transgenic lines were established. Line 28 expresses 50 copies of the transgene. (J:62700)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:62700 Yamashita M, et al., T cell receptor-induced calcineurin activation regulates T helper type 2 cell development by modifying the interleukin 4 receptor signaling complex. J Exp Med. 2000 Jun 5;191(11):1869-79
• All: 1 reference(s)