Tnnt1^tm1.1Jin
Targeted Allele Detail

Summary

• Symbol: Tnnt1^tm1.1Jin
• Name: troponin T1, skeletal, slow; targeted mutation 1.1, Jian-Ping Jin
• MGI ID: MGI:5635255
• Synonyms: Tnnt1-flox
• Gene: Tnnt1 Location: Chr7:4507568-4518974 bp, - strand Genetic Position: Chr7, 2.6 cM
• Alliance: Tnnt1^tm1.1Jin page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:219907
• Parent Cell Line: HM-1 (ES Cell)
• Strain of Origin: 129P2/OlaHsd-Hprt1^b-m3

Mutation description

• Allele Type: Targeted (Conditional ready)
• Mutations: Insertion, Intragenic deletion
• Mutation details: LoxP sites were inserted into intron 10 and intron 13. Flp-mediated recombination removed the FRT-flanked neomycin resistance cassette inserted into intron 10. (J:219907)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Tnnt1 Mutation: 7 strains or lines available

References

• Original: J:219907 Wei B, et al., Deficiency of slow skeletal muscle troponin T causes atrophy of type I slow fibres and decreases tolerance to fatigue. J Physiol. 2014 Mar 15;592(Pt 6):1367-80
• All: 1 reference(s)