Uvrag^{Tn(pb-Act-RFP)1.100107015-HRAZhu}
Transposon induced Allele Detail

Summary

• Symbol: Uvrag^{Tn(pb-Act-RFP)1.100107015-HRAZhu}
• Name: UV radiation resistance associated gene; transposon insertion 1.100107015-HRA, Yuan Zhuang
• MGI ID: MGI:5635118
• Synonyms: UVRAG^PB
• Gene: Uvrag Location: Chr7:98535949-98790373 bp, - strand Genetic Position: Chr7, 53.92 cM
• Alliance: Uvrag^{Tn(pb-Act-RFP)1.100107015-HRAZhu} page

Mutation origin

• Strain of Origin: FVB/NJ

Mutation description

• Allele Type: Transposon induced (Null/knockout)
• Mutation: Transposon insertion
• Mutation details: The transposon containing an unspecified hybrid actin promoter driving expression of red fluorescent protein (RFP) flanked by piggyBac-specific left and right terminal sequences was co-injected with a piggyBac-containing transgene to mobilize the transposon. In line 100107015-HRA, the transposon inserted into intron 14. Western blot analysis confirmed the absence of protein expression in heart, liver, spleen, lung, small intestine and brain. (J:123680, J:219546)

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Uvrag Mutation: 39 strains or lines available

References

• Original: J:219546 Song Z, et al., Essential role for UVRAG in autophagy and maintenance of cardiac function. Cardiovasc Res. 2014 Jan 1;101(1):48-56
• All: 3 reference(s)