Mpc2^em1Finc
Endonuclease-mediated Allele Detail

Summary

• Symbol: Mpc2^em1Finc
• Name: mitochondrial pyruvate carrier 2; endonuclease-mediated mutation 1, Brian Finck
• MGI ID: MGI:5634969
• Synonyms: Mpc2-
• Gene: Mpc2 Location: Chr1:165288829-165308787 bp, + strand Genetic Position: Chr1, 72.8 cM, cytoband H2
• Alliance: Mpc2^em1Finc page

Mutation origin

• Strain of Origin: C57BL/6

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: Zinc finger targeted endonuclease induced a 2bp deletion just downstream of the start codon that resulted in a frameshift mutation. (J:211781)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Mpc2 Mutation: 12 strains or lines available

References

• Original: J:211781 Vigueira PA, et al., Mitochondrial pyruvate carrier 2 hypomorphism in mice leads to defects in glucose-stimulated insulin secretion. Cell Rep. 2014 Jun 26;7(6):2042-53
• All: 1 reference(s)