Oma1^tm1.1Tlan
Targeted Allele Detail

Summary

• Symbol: Oma1^tm1.1Tlan
• Name: OMA1 zinc metallopeptidase; targeted mutation 1.1, Thomas Langer
• MGI ID: MGI:5634778
• Synonyms: Oma1^tm1.1Lan
• Gene: Oma1 Location: Chr4:103171009-103229065 bp, + strand Genetic Position: Chr4, 47.6 cM, cytoband C6
• Alliance: Oma1^tm1.1Tlan page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:210967
• Parent Cell Line: Bruce 4 (ES Cell)
• Strain of Origin: B6.Cg-Thy1^a

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Exon 3 was floxed. Cre mediated recombination then removed exon 3. (J:215813, J:229455)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Oma1 Mutation: 25 strains or lines available

References

• Original: J:210967 Kondadi AK, et al., Loss of the m-AAA protease subunit AFG(3)L(2) causes mitochondrial transport defects and tau hyperphosphorylation. EMBO J. 2014 May 2;33(9):1011-26
• All: 3 reference(s)