Il1r1^tm1.2Quan
Targeted Allele Detail

Summary

• Symbol: Il1r1^tm1.2Quan
• Name: interleukin 1 receptor, type I; targeted mutation 1.2, Ning Quan
• MGI ID: MGI:5634709
• Synonyms: IL1-R1^GR
• Gene: Il1r1 Location: Chr1:40264240-40356417 bp, + strand Genetic Position: Chr1, 18.81 cM
• Alliance: Il1r1^tm1.2Quan page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:219864
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6

Mutation description

• Allele Type: Targeted (Reporter)
• Mutation: Insertion
• Mutation details: Cre-mediated recombination removed the target I sequence between exon IX and exon X of Il1r1^tm1Quan, resulting in expression of functional Il1r1, labeled with P-terminal hemagglutinin tags, and co-expression of tdTomato fluorescent marker from the mRNA. (J:219864)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Il1r1 Mutation: 38 strains or lines available

References

• Original: J:219864 Liu X, et al., Interleukin 1 type 1 receptor restore: a genetic mouse model for studying interleukin 1 receptor-mediated effects in specific cell types. J Neurosci. 2015 Feb 18;35(7):2860-70
• All: 6 reference(s)