Hipk4^{tm1b(KOMP)Mbp}
Targeted Allele Detail

Summary

• Symbol: Hipk4^{tm1b(KOMP)Mbp}
• Name: homeodomain interacting protein kinase 4; targeted mutation 1b, Mouse Biology Program, UC Davis
• MGI ID: MGI:5632532
• Synonyms: Hipk4^-
• Gene: Hipk4 Location: Chr7:27222692-27230600 bp, + strand Genetic Position: Chr7, 15.92 cM
• Alliance: Hipk4^{tm1b(KOMP)Mbp} page
• IMPC: Hipk4 gene page

Mutation origin

• Mutant Cell Line: DEPD0005_5_G07
• Germline Transmission: Earliest citation of germline transmission: J:204739
• Parent Cell Line: JM8A1.N3 (ES Cell)
• Strain of Origin: C57BL/6N-A^tm1Brd
• Project Collection: KOMP-CSD

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion Vector: L1L2_Bact_P
• Mutation details: Cre-mediated excision of the parental Hipk4^{tm1a(KOMP)Mbp} allele resulted in the removal of the promoter-driven neomycin selection cassette and critical exons (exons 2 and 3) leaving behind the inserted lacZ reporter sequence. Further information on targeting strategies used for this and other IKMC alleles can be found at http://www.informatics.jax.org/mgihome/nomen/IKMC_schematics.shtml. PCR of tail-derived genomic DNA and Western blot analyses of whole testis lysates confirmed the absence of functional gene products in homozygous male mice. (J:204739, J:290279)

Expression

In Mice Carrying this Mutation:	9 assay results
In Structures Affected by this Mutation:	5 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Hipk4 Mutation: 19 strains or lines available

References

• Original: J:204739 International Knockout Mouse Consortium, MGI download of modified allele data from IKMC and creation of new knockout alleles. Database Download. 2014-2023
• All: 3 reference(s)