Cyp19a1^{tm2.1(cre)Shah}
Targeted Allele Detail

Summary

• Symbol: Cyp19a1^{tm2.1(cre)Shah}
• Name: cytochrome P450, family 19, subfamily a, polypeptide 1; targeted mutation 2.1, Nirao Shah
• MGI ID: MGI:5632151
• Synonyms: aro^Cre, aromatase^Cre
• Gene: Cyp19a1 Location: Chr9:54073221-54175394 bp, - strand Genetic Position: Chr9, 29.49 cM
• Alliance: Cyp19a1^{tm2.1(cre)Shah} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:220075
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129S/SvEv

Mutation description

• Allele Type: Targeted (Recombinase)
• Mutation: Insertion
• Cyp19a1^{tm2.1(cre)Shah} expression driven by 1 gene
  Knock-in expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Cyp19a1 (MGI:88587)

• Mutation details: A targeting construct was designed to insert an internal ribosomal entry site (IRES) and a Cre recombinase gene, followed by a FRT-flanked neomycin resistance (neo) cassette downstream of the 3' UTR. Flp-mediated recombination removed the FRT-flanked neo cassette. (J:220075)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Cyp19a1 (mouse) Summary of all recombinase alleles driven by Cyp19a1. Comparative matrix view of recombinase activities Alliance mouse Cyp19a1 gene page

Expression

In Mice Carrying this Mutation:

24 assay results

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Cyp19a1 Mutation: 34 strains or lines available

References

• Original: J:220075 Unger EK, et al., Medial amygdalar aromatase neurons regulate aggression in both sexes. Cell Rep. 2015 Feb 3;10(4):453-62
• All: 4 reference(s)