Hprt1^{tm6(CAG-fat-1)Geno}
Targeted Allele Detail

Summary

• Symbol: Hprt1^{tm6(CAG-fat-1)Geno}
• Name: hypoxanthine phosphoribosyltransferase 1; targeted mutation 1, Genoway
• MGI ID: MGI:5629842
• Synonyms: iFat1
• Gene: Hprt1 Location: ChrX:52077014-52110536 bp, + strand Genetic Position: ChrX, 29.31 cM, cytoband A6
• Alliance: Hprt1^{tm6(CAG-fat-1)Geno} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:213660
• Parent Cell Line: E14TG2a (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Inserted expressed sequence)
• Mutation: Insertion
• Mutation details: The targeting construct introduced into the locus a CAG promoter, floxed stop cassette, the C. elegans omega-3 fatty acid desaturase (fat-1) cDNA which was modified to optimize codon usage for mammalian cells, and a polyadenylation sequence. (J:213660)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Hprt1 Mutation: 1274 strains or lines available

References

• Original: J:213660 Clarke SE, et al., The iFat1 transgene permits conditional endogenous n-3 PUFA enrichment both in vitro and in vivo. Transgenic Res. 2014 Jun;23(3):489-501
• All: 2 reference(s)