Prepl^tm1.2Sagh
Targeted Allele Detail

Summary

• Symbol: Prepl^tm1.2Sagh
• Name: prolyl endopeptidase-like; targeted mutation 1.2, Alan Saghatelian
• MGI ID: MGI:5629515
• Synonyms: PREPL^-
• Gene: Prepl Location: Chr17:85370898-85397669 bp, - strand Genetic Position: Chr17, 55.19 cM
• Alliance: Prepl^tm1.2Sagh page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:213429
• Parent Cell Line: v6.5 (ES Cell)
• Strain of Origin: (C57BL/6 x 129S4/SvJae)F1

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Cre-mediated recombination removed the floxed exon 11. This allele also lacks the selection cassette found in the originally targeted allele. Western blot analysis confirmed the absence of protein in spinal cord. (J:213429)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Prepl Mutation: 27 strains or lines available

References

• Original: J:213429 Lone AM, et al., Deletion of PREPl causes growth impairment and hypotonia in mice. PLoS One. 2014;9(2):e89160
• All: 1 reference(s)