Tll1^tm2.1Dgr
Targeted Allele Detail

Summary

• Symbol: Tll1^tm2.1Dgr
• Name: tolloid-like; targeted mutation 2.1, Daniel S Greenspan
• MGI ID: MGI:5629408
• Synonyms: Tll1^flox, Tll1^loxP
• Gene: Tll1 Location: Chr8:64467965-64659305 bp, - strand Genetic Position: Chr8, 32.19 cM
• Alliance: Tll1^tm2.1Dgr page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:210366
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted (Conditional ready)
• Mutation: Insertion
• Mutation details: A loxP site was inserted upstream of exon 6. An FRT-flanked neomycin resistance cassette with a 3' loxP site was inserted downstream of exon 6. Flp-mediated recombination removed the selection cassette and left exon 6 floxed. (J:210366)

Disease models

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Tll1 Mutation: 69 strains or lines available

Notes

Phenotypic Similarity to Human Syndrome: Osteogenesis Imperfecta J:210366.

References

• Original: J:210366 Muir AM, et al., Induced ablation of Bmp1 and Tll1 produces osteogenesis imperfecta in mice. Hum Mol Genet. 2014 Jun 15;23(12):3085-101
• All: 5 reference(s)