Gt(ROSA)26Sortm1(CAG-MFN2*T105M)Dple
Targeted Allele Detail
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Symbol: |
Gt(ROSA)26Sortm1(CAG-MFN2*T105M)Dple |
Name: |
gene trap ROSA 26, Philippe Soriano; targeted mutation 1, David Pleasure |
MGI ID: |
MGI:5629288 |
Synonyms: |
Rosa-STOP-MFN2T105M |
Gene: |
Gt(ROSA)26Sor Location: Chr6:113044389-113054205 bp, - strand Genetic Position: Chr6, 52.73 cM
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Alliance: |
Gt(ROSA)26Sortm1(CAG-MFN2*T105M)Dple page
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Germline Transmission: |
Earliest citation of germline transmission:
J:251584
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Parent Cell Line: |
Not Specified (ES Cell)
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Strain of Origin: |
C57BL/6
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Allele Type: |
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Targeted (Conditional ready, Humanized sequence, Inserted expressed sequence, No functional change) |
Mutations: |
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Insertion, Nucleotide substitutions
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Gt(ROSA)26Sortm1(CAG-MFN2*T105M)Dple expresses
1 gene
Knock-in expresses:
Organism |
Expressed Gene |
Homolog in Mouse |
Note |
human |
MFN2 (9927) |
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Mutation details: A targeting vector containing a floxed STOP-NEO cassette, a human MFN2 cDNA carrying the T105M mutation, and human growth hormone poly A sequences under the control of the CAG promoter is inserted into the Gt(ROSA)26Sor locus.
(J:251584)
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View phenotypes and curated references for all genotypes (concatenated display).
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Original: |
J:251584 Bannerman P, et al., Mice Hemizygous for a Pathogenic Mitofusin-2 Allele Exhibit Hind Limb/Foot Gait Deficits and Phenotypic Perturbations in Nerve and Muscle. PLoS One. 2016;11(12):e0167573 |
All: |
5 reference(s) |
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