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Targeted Allele Detail
Symbol: Gt(ROSA)26Sortm1(CAG-MFN2*T105M)Dple
Name: gene trap ROSA 26, Philippe Soriano; targeted mutation 1, David Pleasure
MGI ID: MGI:5629288
Synonyms: Rosa-STOP-MFN2T105M
Gene: Gt(ROSA)26Sor  Location: Chr6:113044389-113054205 bp, - strand  Genetic Position: Chr6, 52.73 cM
Alliance: Gt(ROSA)26Sortm1(CAG-MFN2*T105M)Dple page
Germline Transmission:  Earliest citation of germline transmission: J:251584
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  C57BL/6
Allele Type:    Targeted (Conditional ready, Humanized sequence, Inserted expressed sequence, No functional change)
Mutations:    Insertion, Nucleotide substitutions
Gt(ROSA)26Sortm1(CAG-MFN2*T105M)Dple expresses 1 gene
Mutation detailsA targeting vector containing a floxed STOP-NEO cassette, a human MFN2 cDNA carrying the T105M mutation, and human growth hormone poly A sequences under the control of the CAG promoter is inserted into the Gt(ROSA)26Sor locus. (J:251584)
View phenotypes and curated references for all genotypes (concatenated display).
Disease models
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Gt(ROSA)26Sor Mutation:  834 strains or lines available
Original:  J:251584 Bannerman P, et al., Mice Hemizygous for a Pathogenic Mitofusin-2 Allele Exhibit Hind Limb/Foot Gait Deficits and Phenotypic Perturbations in Nerve and Muscle. PLoS One. 2016;11(12):e0167573
All:  5 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
MGI 6.22
The Jackson Laboratory