Fpgs^tm1.2Rmor
Targeted Allele Detail

Summary

• Symbol: Fpgs^tm1.2Rmor
• Name: folylpolyglutamyl synthetase; targeted mutation 1.2, Richard G Moran
• MGI ID: MGI:5621189
• Gene: Fpgs Location: Chr2:32572621-32594157 bp, - strand Genetic Position: Chr2, 22.09 cM
• Alliance: Fpgs^tm1.2Rmor page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:212033
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129

Mutation description

• Allele Type: Targeted (Modified isoform(s))
• Mutations: Insertion, Intragenic deletion
• Mutation details: Cre-mediated recombination removed exons A1a, A1b and the selection cassette. Expression from promoter 1 is abolished. (J:212033)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Fpgs Mutation: 29 strains or lines available

References

• Original: J:212033 Yang C, et al., Humanizing mouse folate metabolism: conversion of the dual-promoter mouse folylpolyglutamate synthetase gene to the human single-promoter structure. FASEB J. 2014 May;28(5):1998-2008
• All: 1 reference(s)