Mtf1tm1c(KOMP)Wtsi
Targeted Allele Detail
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Symbol: |
Mtf1tm1c(KOMP)Wtsi |
Name: |
metal response element binding transcription factor 1; targeted mutation 1c, Wellcome Trust Sanger Institute |
MGI ID: |
MGI:5621187 |
Synonyms: |
Mtf1fl |
Gene: |
Mtf1 Location: Chr4:124696342-124743593 bp, + strand Genetic Position: Chr4, 57.91 cM, cytoband D1
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Alliance: |
Mtf1tm1c(KOMP)Wtsi page
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IMPC: |
Mtf1 gene page |
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Germline Transmission: |
Earliest citation of germline transmission:
J:212038
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Parent Cell Line: |
JM8.N4 (ES Cell)
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Strain of Origin: |
C57BL/6N
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Project Collection: |
KOMP-CSD
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Allele Type: |
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Targeted (Conditional ready) |
Mutation: |
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Insertion
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Mutation details: The L1L2_gt0 cassette was inserted at position 124713564 of Chromosome 4 upstream of the critical exon(s) (Build GRCm39). The cassette is composed of an FRT flanked lacZ/neomycin sequence followed by a loxP site. An additional loxP site is inserted downstream of the targeted exon(s) at position 124714524. The critical exon(s) is/are thus flanked by loxP sites. A "conditional ready" (floxed) allele was created by flp recombinase expression in mice carrying this allele to remove the lacZ sequence and neo selection cassette, leaving loxP sites flanking the critical exon(s).
(J:212038)
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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Carrying any Mtf1 Mutation: |
38 strains or lines available
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Original: |
J:212038 Kim JH, et al., Regulation of the catabolic cascade in osteoarthritis by the zinc-ZIP8-MTF1 axis. Cell. 2014 Feb 13;156(4):730-43 |
All: |
1 reference(s) |
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