Dll1^tm3.1Gos
Targeted Allele Detail

Summary

• Symbol: Dll1^tm3.1Gos
• Name: delta like canonical Notch ligand 1; targeted mutation 3.1, Achim Gossler
• MGI ID: MGI:5620942
• Synonyms: Dll1^{Dll1T638V,S693A,S696A}
• Gene: Dll1 Location: Chr17:15587616-15597134 bp, - strand Genetic Position: Chr17, 8.95 cM
• Alliance: Dll1^tm3.1Gos page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:213529
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Hypomorph, Inserted expressed sequence)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A Dll1 minigene (exons 1 to 9 as cDNA followed by the remainder of the Delta1 gene intron 9, exon 10, intron 10, and exon 11) with nucleotide substitutions that result in the amino acid substitutions of valine for threonine at postition 638 (T638V) and alanine for serine at positions 693 (S693A) and and 696 (S696A) and a floxed neomycin resistance cassette were inserted downstream of exon 1. Cre-mediated recombination removed the selection cassette. (J:213529)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Dll1 Mutation: 46 strains or lines available

References

• Original: J:213529 Braune EB, et al., S/T phosphorylation of DLL1 is required for full ligand activity in vitro but dispensable for DLL1 function in vivo during embryonic patterning and marginal zone B cell development. Mol Cell Biol. 2014 Apr;34(7):1221-33
• All: 1 reference(s)