Igfbp7^tm1.1Dds
Targeted Allele Detail

Summary

• Symbol: Igfbp7^tm1.1Dds
• Name: insulin-like growth factor binding protein 7; targeted mutation 1.1, Demetri D Spyropoulos
• MGI ID: MGI:5618913
• Gene: Igfbp7 Location: Chr5:77497092-77555892 bp, - strand Genetic Position: Chr5, 41.71 cM
• Alliance: Igfbp7^tm1.1Dds page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:212964
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: A loxP site was inserted upstream of exon 1 and a floxed neo selection cassette was inserted in intron 1. Exon 1 was excised using a viral vector expressing cre. The neo selection cassette remained. (J:212964)

Expression

In Mice Carrying this Mutation:	1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Igfbp7 Mutation: 19 strains or lines available

References

• Original: J:212964 Chatterjee S, et al., Loss of Igfbp7 causes precocious involution in lactating mouse mammary gland. PLoS One. 2014;9(2):e87858
• All: 1 reference(s)