Slc7a5^tm1.2Daca
Targeted Allele Detail

Summary

• Symbol: Slc7a5^tm1.2Daca
• Name: solute carrier family 7 (cationic amino acid transporter, y+ system), member 5; targeted mutation 1.2, Doreen A Cantrell
• MGI ID: MGI:5618524
• Gene: Slc7a5 Location: Chr8:122607885-122634425 bp, - strand Genetic Position: Chr8, Syntenic
• Alliance: Slc7a5^tm1.2Daca page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:213820
• Parent Cell Line: E14 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: The targeting vector contains loxP sites flanking exon 1, including the initiation codon. An FRT-flanked neomycin resistance (neo) cassette fused to an internal ribosomal entry site (IRES) and a splice donor (SD) sequence, followed by a third loxP site, are placed downstream of exon 1. Flp-mediated recombination removed the FRT-flanked neo-IRES-SD cassette. Cre-mediated recombination removed exon1. (J:213820)

Expression

In Mice Carrying this Mutation:

52018 assay results 1 RNA-Seq or microarray experiment(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Slc7a5 Mutation: 31 strains or lines available

References

• Original: J:213820 Poncet N, et al., The catalytic subunit of the system L1 amino acid transporter (slc7a5) facilitates nutrient signalling in mouse skeletal muscle. PLoS One. 2014;9(2):e89547
• All: 2 reference(s)