Srcin1^tm1Fdc
Targeted Allele Detail

Summary

• Symbol: Srcin1^tm1Fdc
• Name: SRC kinase signaling inhibitor 1; targeted mutation 1, Ferdinando Di Cunto
• MGI ID: MGI:5617962
• Synonyms: p140Cap^-
• Gene: Srcin1 Location: Chr11:97400166-97466059 bp, - strand Genetic Position: Chr11, 61.0 cM, cytoband D
• Alliance: Srcin1^tm1Fdc page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:206962
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Disruption caused by insertion of vector
• Mutation details: A neomycin cassette was inserted into exon 8. Western blot analysis confirmed absence of protein expression in total brain lysates from homozygous mutant mice. (J:206962)

Expression

In Mice Carrying this Mutation:	9 assay results
In Structures Affected by this Mutation:	2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Srcin1 Mutation: 52 strains or lines available

References

• Original: J:206962 Repetto D, et al., p140Cap regulates memory and synaptic plasticity through Src-mediated and citron-N-mediated actin reorganization. J Neurosci. 2014 Jan 22;34(4):1542-53
• All: 5 reference(s)