Kiss1r^tm1.1Hjn
Targeted Allele Detail

Summary

• Symbol: Kiss1r^tm1.1Hjn
• Name: KISS1 receptor; targeted mutation 1.1, Horacio Novaira
• MGI ID: MGI:5617953
• Gene: Kiss1r Location: Chr10:79752805-79758107 bp, + strand Genetic Position: Chr10, 39.72 cM
• Alliance: Kiss1r^tm1.1Hjn page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:212351
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Conditional ready)
• Mutation: Insertion
• Mutation details: An FRT flanked neo cassette was inserted in intron 2 followed by a loxP site. A second loxP site was inserted upstream of exon 2. The neo cassette was subsequently excised by frt expression leaving exon 2 flanked by loxP sites. (J:212351)

Expression

In Structures Affected by this Mutation:

10 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Kiss1r Mutation: 20 strains or lines available

References

• Original: J:212351 Novaira HJ, et al., Disrupted kisspeptin signaling in GnRH neurons leads to hypogonadotrophic hypogonadism. Mol Endocrinol. 2014 Feb;28(2):225-38
• All: 4 reference(s)