Gbp5^em2Broz
Endonuclease-mediated Allele Detail

Summary

• Symbol: Gbp5^em2Broz
• Name: guanylate binding protein 5; endonuclease-mediated mutation 2, Petr Broz
• MGI ID: MGI:5617741
• Gene: Gbp5 Location: Chr3:142202695-142228105 bp, + strand Genetic Position: Chr3, 66.69 cM
• Alliance: Gbp5^em2Broz page

Mutation origin

• Strain of Origin: C57BL/6N

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: Zinc finger nuclease activity resulted in a 1 bp deletion in exon 2. This deletion leads to a frameshift and premature stop codon. (J:210626)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Gbp5 Mutation: 39 strains or lines available

References

• Original: J:210626 Meunier E, et al., Caspase-11 activation requires lysis of pathogen-containing vacuoles by IFN-induced GTPases. Nature. 2014 May 15;509(7500):366-70
• All: 1 reference(s)