Ikzf1^tm3Kge
Targeted Allele Detail

Summary

• Symbol: Ikzf1^tm3Kge
• Name: IKAROS family zinc finger 1; targeted mutation 3, Katia Georgopoulos
• MGI ID: MGI:5617014
• Synonyms: IkE5^fl
• Gene: Ikzf1 Location: Chr11:11634980-11722926 bp, + strand Genetic Position: Chr11, 7.02 cM
• Alliance: Ikzf1^tm3Kge page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:209927
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Conditional ready)
• Mutation: Insertion
• Exon 5, which encodes two Ikaros DNA-binding zinc fingers, was floxed via homologous recombination. (J:209927)

Expression

In Mice Carrying this Mutation:

1 RNA-Seq or microarray experiment(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ikzf1 Mutation: 30 strains or lines available

References

• Original: J:209927 Joshi I, et al., Loss of Ikaros DNA-binding function confers integrin-dependent survival on pre-B cells and progression to acute lymphoblastic leukemia. Nat Immunol. 2014 Mar;15(3):294-304
• All: 3 reference(s)