Krastm1Dsa
Targeted Allele Detail
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Symbol: |
Krastm1Dsa |
Name: |
Kirsten rat sarcoma viral oncogene homolog; targeted mutation 1, Dieter Saur |
MGI ID: |
MGI:5616879 |
Synonyms: |
FSF-KrasG12D |
Gene: |
Kras Location: Chr6:145162425-145195965 bp, - strand Genetic Position: Chr6, 77.37 cM, cytoband G2
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Alliance: |
Krastm1Dsa page
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Germline Transmission: |
Earliest citation of germline transmission:
J:218155
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Parent Cell Line: |
Not Specified (ES Cell)
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Strain of Origin: |
129S6/SvEvTac
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Allele Type: |
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Targeted (Conditional ready, Null/knockout) |
Mutations: |
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Insertion, Nucleotide substitutions
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Mutation details: Glycine codon 12 in exon 2 was changed to aspartic acid. An FRT site flanked STOP cassette with a splice acceptor 3' of the first FRT site and a promoterless neomycin resistance gene cassette were introduced into intron 1.
(J:218155)
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List all tumor models in MMHCdb carrying
Krastm1Dsa
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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Carrying any Kras Mutation: |
76 strains or lines available
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Original: |
J:218155 Schonhuber N, et al., A next-generation dual-recombinase system for time- and host-specific targeting of pancreatic cancer. Nat Med. 2014 Nov;20(11):1340-7 |
All: |
17 reference(s) |
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