Mir155^tm1.1Ggard
Targeted Allele Detail

Summary

• Symbol: Mir155^tm1.1Ggard
• Name: microRNA 155; targeted mutation 1.1, Gwenn Garden
• MGI ID: MGI:5616592
• Synonyms: MiR155^fl
• Gene: Mir155 Location: Chr16:84511028-84511092 bp, + strand Genetic Position: Chr16, 46.92 cM
• Alliance: Mir155^tm1.1Ggard page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:218084
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: The targeting vector contains an FRT-flanked PGK-neomycin selection cassette, followed by a loxP site inserted downstream of exon 2 of the targeted gene, and another loxP site inserted upstream of this coding exon. The neomycin cassette was deleted by transient transfection of a flp recombinase expression vector in the ES cells. (J:218084)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Mir155 Mutation: 11 strains or lines available

References

• Original: J:218084 Hu R, et al., miR-155 promotes T follicular helper cell accumulation during chronic, low-grade inflammation. Immunity. 2014 Oct 16;41(4):605-19
• All: 11 reference(s)