b2b2815Clo
Chemically induced Allele Detail

Summary

• Symbol: b2b2815Clo
• Name: Mutant line 2815; Bench to Bassinet Program (B2B/CVDC), mutation 2815 Cecilia Lo
• MGI ID: MGI:5616525
• Gene: b2b2815Clo Location: unknown
• Alliance: b2b2815Clo page

Mutant (E15.5) presents with parallel outflow tracts which was diagnosed as overriding aorta by ECM imaging

Show the 10 phenotype image(s) involving this allele.

Mutation origin

• Strain of Origin: C57BL/6J
• Project Collection: B2B/CvDC

Mutation description

• Allele Type: Chemically induced (ENU)
• Mutation: Undefined
• This ENU-induced mutation was isolated in a screen at the University of Pittsburgh.

Expression

In Structures Affected by this Mutation:

7 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any b2b2815Clo Mutation: 0 strains or lines available

Notes

Summative Diagnosis:
Cardiovascular phenotypes: Overriding aorta and perimembranous ventricular septal defect (pmVSD), ventricular hypertrophy

Noncardiovascular phenotype: Craniofacial defects including short snout, micrognathia, agnathia, anopthalmia, low set ears, and cleft palate, multiplex kidneys

Fyler Codes
The Fyler code developed by The Boston Children's Heart Foundation in Boston Children's Hospital provides a hierarchical clinical diagnosis of congenital cardiovascular defects and other disorders. These codes are used to delineate pathology in the mutant mouse models that parallel human disease and can be cross referenced to the International Pediatric and Congenital Cardiac Code (IPCCC) (http://www.ipccc.net/).

Fyler Codes	Code Description
1310	Ventricular septal defect, membranous
1432	Overriding aortic valve
4163	Micrognathia
4864	Anophthalmia
4876	Cleft palate

References

• Original: J:175213 Lo C, Information submitted by the NHLBI Cardiovascular Development Consortium (CvDC), Bench to Bassinet Program (B2B/CvDC). MGI Direct Data Submission (B2B/CvDC). 2011-09-12
• All: 2 reference(s)