Selenop^tm4.1Rfb
Targeted Allele Detail

Summary

• Symbol: Selenop^tm4.1Rfb
• Name: selenoprotein P; targeted mutation 4.1, Raymond F Burk
• MGI ID: MGI:5616347
• Synonyms: Sepp1^U40S
• Gene: Selenop Location: Chr15:3300249-3309992 bp, + strand Genetic Position: Chr15, 1.84 cM
• Alliance: Selenop^tm4.1Rfb page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:211934
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Inserted expressed sequence)
• Mutation: Insertion
• Mutation details: A self excising neo selection cassette was inserted before exon 2 and the codon for the first selenocysteine was altered from TGA to TCA, which encodes serine (U40S). (J:211934)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Selenop Mutation: 22 strains or lines available

References

• Original: J:211934 Kurokawa S, et al., Sepp1(UF) forms are N-terminal selenoprotein P truncations that have peroxidase activity when coupled with thioredoxin reductase-1. Free Radic Biol Med. 2014 Apr;69:67-76
• All: 1 reference(s)